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Keratoconus is one of the most common causes of application of hard contact lenses, in less frequent cases of soft contact lenses. It is a degenerative, progressive, non-inflammatory eye disease, and most bilateral disease of cornea. It is characterized by excessive bowing and by reduction of thickness of cornea, usually centrally or paracentrally, slightly lower temporal or intranasally. The eye disease is accompanied by biochemical changes in corneal tissue. In the stroma, at the same time there is an increased proportion of enzymes that encourage the building of tissues, and reduced the proportion of enzymes that cause apoptosis, programmed cell death. This reduces the regulatory number of cells. On corneal eye disease shows also reduced number of enzymes that break down tissues harmful metabolic products. Some of the cells are irreversibly damaged, the activity of the others can be restored. |
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